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KMID : 0387420030140010001
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Korean Society of Oriental Neuropsychiatry
2003 Volume.14 No. 1 p.1 ~ p.16
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Effects of Hwangryeonhaedoktang on Depression and c-Fos Expression in Paraventricular Nucleus of the Brain in the Chronic Mild Stress Treated Rats
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Jung Seon-Yong
Kim Jong-Woo
Lee Jung-Ryun
Jang Hyun-Ho
Kim Hyun-Taek
Hwang Wei-Wan
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Abstract
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Objective: This study was designed to assess the protective effects of Hwangryeonhaedoktang on the animal model of depression, induced by chronic mild stress(CMS).
Method: Male Sprague-Dawley rats were used for this experiment. The subjects were divided into 3 groups ( 1. CMS-drug: Hwangryeonhaedoktang administered during CMS treatment, 2. CMS-vehicle: water administered, 3. normal ). After 4 weeks of CMS treatment, they were executed forced swimming test(FST), open field test and c-Fos in paraventricular nucleus(PVN) were measured.
Results: 1. In FST, immobility behavior decreased significantly in CMS-drug group. 2. There was no difference in the open field test between 3 groups 3. c-Fos expressed cell bodies in PVN were significantly less in CMS-drug than in CMS-vehicle group.
Conclusion:These results suggest that Hwangryeonhaedoktang may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated stress-copying behaviors which are related with PVN of hypothalamus.
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KEYWORD
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Hwangryeonhaedoktang, chronic mild stress, forced swimming test, open field test, c-Fos
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